Author Archives: RobertKamper

Music, Parkinson's, Research , , Leave a comment

Advice to People with PD: Sing while you walk

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Internal cueing improves gait more than external cueing in healthy adults and people with Parkinson disease 

Results indicate that internal cueing was associated with improvements in gait velocity, cadence, and stride length in the backward direction, and reduced variability in both forward and backward walking. In comparison, external cueing was associated with minimal improvement in gait characteristics and a decline in gait stability. People with gait impairment due to aging or neurological decline may benefit more from internal cueing techniques such as singing as compared to external cueing techniques.

The feasibility of singing to improve gait in Parkinson disease.

Abstract

Brain regions important for controlling movement are also responsible for rhythmic processing. In Parkinson disease (PD), defective internal timing within the brain has been linked to impaired beat discrimination, and may contribute to a loss of ability to maintain a steady gait rhythm. Less rhythmic gait is inherently less efficient, and this may lead to gait impairment including reduced speed, cadence, and stride length, as well as increased variability. While external rhythmic auditory stimulation (e.g. a metronome beat) is well-established as an effective tool to stabilize gait in PD, little is known about whether self-generated cues such as singing have the same beneficial effect on gait in PD. Thus, we compared gait patterns of 23 people with mild to moderate PD under five cued conditions: uncued, music only, singing only, singing with music, and a verbal dual-task condition. In our single-session study, singing while walking did not significantly alter velocity, cadence, or stride length, indicating that it was not excessively demanding for people with PD. In addition, walking was less variable when singing than during other cued conditions. This was further supported by the comparison between singing trials and a verbal dual-task condition. In contrast to singing, the verbal dual-task negatively affected gait performance. These findings suggest that singing holds promise as an effective cueing technique that may be as good as or better than traditional cueing techniques for improving gait among people with PD.

 

Parkinson's, Research, Reviews , , Leave a comment

Amyloid-Beta and Parkinson’s Disease

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Amyloid-Beta and Parkinson’s Disease    (abstract only but list of references includes many available on PubMed)

From the abstract:

A better understanding of the role of this system and more specifically the role of Aβ in PD symptomatology, could introduce new treatment and repurposing drug-based strategies. For instance, apomorphine infusion has been shown to promote the degradation of Aβ in rodent models. This is further supported in a post-mortem study in PD patients although clinical implications are unclear. In this review, we address the clinical implication of cerebral Aβ deposition in PD and elaborate on its metabolism, its role in cognition and motor function/gait, and finally assess the potential effect of apomorphine on Aβ deposition in PD.

So it would seem that apomorphine might be a tool for helping with gait and balance problems…and cognitive decline.
 

Exercise, Parkinson's, Research, Reviews , , , , Leave a comment

Biomarkers,cardio training, singing and dancing, and how jokes work.

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This is a long post. Most of the links are to free, full text articles or reports.

Recent advances in Biomarkers for Parkinson’s A review of the advances currently being made in the search for a cure.

INTERVAL TRAINING FOR CARDIOMETABOLIC AND BRAIN HEALTH

 

1. Engaging in interval exercise can boost fitness and improve your mood in a time-efficient manner.

2. Short exercise breaks like climbing the stairs can refocus attention and help maintain productivity in the workplace.

3. Combining interval exercises with motor skill training in a clinical setting can augment the recovery of function.

Dance and Health Training research report   

The aim of this research was to create a best practice model of dance and health continuing professional development (CPD); to create a dynamic, interdisciplinary course of study for dancers who are engaged in facilitating dance across a range of dance genres within health care contexts.

Outcomes of the project:  Full listing of international and national examples of best practice, core literature, key expert practitioners, full course content and delivery requirements are set out in this report.

(Note: specifically related to Ireland).

Sing while you work

This pilot study is the first Irish study of the health and wellbeing benefits of HSE workplace choirs. It is one of few studies to investigate the health and
wellbeing benefits of choir for Health Service Staff internationally.  Qualitative data confirms previous study findings; namely that a workplace choir can promote social connectedness, enjoyment at work, and staff
engagement; reduce stress; and improve perception of health and wellbeing.
Benefits of attending are noticed across workplace communications.

Comparison of two different exercise programs  (abstract only)

After treatment, UPDRS-II scores improved (mean change: EXE, -4.5 points; CYC, -3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, -2.5 and -2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all p < 0.05, but there was no difference between groups). EXE vs. CYC resulted in improved SE-ADL (8.4 and 4.0 points, effect size [ES]: 0.12), BBS (8.8 and 4.2 points, ES: 0.44), and 2 measures of posturography (ES: 0.11 and 0.21) (p 0.05).

CONCLUSION:
Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.

One thing Parkinson’s People do to help cope with  an incurable (so far), progressive, degenerative, neurological disease is to use humor.

The following showed up in the Dance+Parkinson’s search feed, and are included here with a caveat that some of the jokes used to illustrate the ways in which humor works (theoretically) can be be considered offensive.

How do jokes work?

Back before the Internet, there was a Humor list-serve, dedicated to the study of humor and how it works.  The above PDF attempts to address the varieties of jokes, and repeats some potentially offensive ones to illustrate its concepts. Much of the text refers to the following free e-book on the Gutenberg project.

Laughter: an essay on the meaning of humor   by Henri Bergson

 

 

 

Dance for Parkinson's, Music, Parkinson's, Research, Reviews , , , , Leave a comment

Music, Rhythm, etc.

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therapeutic effects of singing on neurological diseases Don’t know if I’ve sent this out before. A review of benefits of singing on PD and other conditions.

“Walking to New Orleans” or rhythmic auditory cues improve gait

Results

Gait variability decreased and prefrontal HbO2 levels increased during cued walking relative to usual

walking. Older adults showed greater HbO2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning and reduced gait variability were linked with increased HbO2 levels during RAC walking.

Conclusion

These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task

 

THE BEAT GOES ON AUDITORY CUES FOR PEOPLE WITH PARKINSON’S DISEASE A Powerpoint presentation that covers everything you might want to know about PD and auditory cues. Basically, folks did as well or better with music than a metronome beat, and enjoyed walking to music better. significant results reported and apparently both CMTs and PTs were in agreement.
 
Not Cure but heal: Music and Medicine  a chapter in a book, but the references are listed, and some of them are available free on PubMed Central

Internal cues better than external in improving gait

Results indicate that internal cueing was associated with improvements in gait velocity, cadence, and stride length in the backward direction, and reduced variability in both forward and backward walking. In comparison, external cueing was
associated with minimal improvement in gait characteristics and a decline in gait stability. People with gait impairment due to aging or neurological decline may benefit more from internal cueing techniques such as singing as compared to external cueing techniques.
Meter and learning (open access article) Both dance and music performers must learn timing patterns (temporal learning, or ‘when‘) along with series of different movements (ordinal learning, or ‘what‘). It has been suggested that the organization of temporal events into regular beat cycles (meter strength) may enhance both temporal and ordinal learning, but empirical evidence is mixed and incomplete. In the present study, we examined meter-strength effects on the concurrent temporal and ordinal learning of sequences. Meter strength enhanced ordinal learning (‘what’) when the concurrent temporal learning was incidental, but it had no effects on temporal learning itself (‘when’). Our findings provide guidelines for dance and music teaching as well as rhythm-based neurological rehabilitation.
 
just catching up on my inbox.
I got rhythm, I got music, and if I quote more than that UMG’s lawyers will probably sue me, too.
Music, Parkinson's, Research, Uncategorized Leave a comment

A few good links

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Biorxiv .    

Biorix is an open access repository for pre-print articles, hosted by the Cold Spring Harbor Laboratory  The above link is a search for articles related to parkinson’s Disease, but there are many other fields covered. Their motto or subtitle is “Advancing the frontiers of biology through research & education.”

The Science of Parkinson’s blog

The Science of Parkinson’s is a blog run by a fellow named Simon who likes to include interesting graphics with his posts.. Also has a Facebook page, where mainly  posts link to the blog entries a they come out Facebook page

PubMed  

PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. If you like to read the full articles and not just the abstracts, this is the place to go: PubMed Help on getting journal articles. 

Or if you’re as lazy as I am, just choose the Open Access and last 10 years filters.

Research , Leave a comment

Reward Deficiency Syndrome

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I’ve been reading on a couple of topics recently – One is basically on music training and neuro-rehabilitation in neuro-degenerative diseases. The other is on what is theorized as the reward system in the brain, which includes the dopamine generating neurons, and the deficiency of dopamine, which factors into several different conditions. apparently ADHD, addictions to substances such as alcohol and cocaine, and narcolepsy are included.  (What? no mention of Parkinson’s?)

The article appears in Volume 1, issue 1,  2015, of the Journal of Reward Deficiency Synddromne at http://dx.doi.org/10.17756/jrds.2015-002  which is an online journal focused primarily on addictions and treatments. Other, more recent articles can be accessed freely. Worth a look, if ADHD and addictions are your field of interest.

As someone with a narcolepsy without cataplexy diagnosis, the article is interesting, especially since I have never been diagnosed as ADHD, which the authoors theorize are closely connected. Howewver, as one who has been known to multi-task well in the past, perhaps the ADHD element was never noticed because of my high IQ (g-intelligence, as some would call it). I could get away with reading Mad magazine in geometry class, tucked inside my  textbook, because I could keep up with the class while shifting my attention between the magazine, the teacher’s explanations, and the drawings on the chalkboard. Now, having slowed down due to Parrkinson’s, it might be apparent in he number of tasks started and left undone, the distractions of Facebook, and a general disorder.

Anyway, worth a thought or two of considefration…

 

 

Music, Parkinson's, Research, Reviews, Uncategorized , Leave a comment

Music Training and PD

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A Rationale for Muusic Training To Enhance Executive Function in Parkinson’s Disease: An Overview of the Problem

From the abstract:: “Deficits in executive functions (e.g., attention, processing speed) in patients with PD result in gait interference, deficits in emotional processing, loss of functional capacity (e.g., intellectual activity, social participation), and reduced quality of life. ” (for people with Parkinson’s Disease.

The authors note that music listening interventions can help with gait and freezing, but that the effecct of actual musical training on executive functions mentioned above is unknown.

“In piano training, fine motor finger movements activate the cerebellum and supplementary motor areas (SMA) , thereby exercising the CTC network. We hypothesize that exercising the CTC network through music training will contribute to enhanced executive functions. Previous research suggested that music training enhances cognitive performance (i.e., working memory and processing speed) in healthy adults and adults with cognitive impairments. ”

” Previous research suggested that music training enhances cognitive performance (i.e., working memory and processing speed) in healthy adults and adults with cognitive impairments. This review and rationale provides support for the use of music training to enhance cognitive outcomes in patients with Parkinson’s Disease (PD).”

The evidence revewed in the article “presents a compelling case for music training to improve executive functioning for adults with PD.

“First, music training activates the cerebellar-thalamocortical network (CTC) network providing a rerouting to activate executive functions through fine motor activity .”

The authors “hypothesize that exercising the CTC network through music training will contribute to enhanced cognitive performance.

The Movement Disorder Society (MDS) values the identification and intervention of cognitive impairment in adults with PD, and sees it as part of essential care—a need yet to be met.”

“Cognitive interventions that include repeated practice exercising the CTC network through sensorimotor integration may assist patients with PD. While research has shown that music training enhances cognitive performance (i.e., working memory and processing speed) in healthy older adults, there is a need to extend the benefits of music training to patients with PD.”

Please excuse me, time for my keyboard practice.
Dance for Parkinson's, Music, Parkinson's, Research , , Leave a comment

Some references on Dance + Parkinson’s Disease + Singing + Music … for reading and assimilation

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The overall arc of research on music is that it does more than soothe the savagw breast [ it mrnds the mind, provides rhythmic cues and aids in movement and balance, and singing helps with breathing and volume. Here are just three references – the third has to do with autism spectrum disorder, but what the heck, worth a read, and perhaps one can extrapolate to PD, if not generalize…

Evaluating Dancing With Parkinson’s: Reflections from the perspective of a community organization 

The neurochemistry of music

Effects of Dance Therapy

 

 

Slices of Life Leave a comment

From: Whatever… to: Whatever It Takes

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An old tee shirt of mine shows a cartoon face with shrugging shoulders and a Key West, FL logo with the word “Whatever …” as the main message.

I now have a wristband from the Parkinson’s Foundation that says “Whatever It Takes – To Beat Parkinon’s”

So that is how my attitude has changed following my PD diagnosis.

My Dad used to say that his philosophy of life was “Que sera, sera – whatever will be, will be”. Later on, he covered up his loss of hearing by saying “Whatever…”

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So now we begin again.

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This blog has been on hiatus for nearly a year, bu I have some fairly decent excuses – a recurring case pf cystitis, a bunion that  was attempted by one surgeon, then after six months, found out the real reason my foot was still swollen was that the screws holding the plate waer too long and were causing irritation of the next metatarsal – so it has been 8 going on 9 months of limited mobility and limited opportunity to hit all buy the highest priorities.

Like getting to the bathroom before it’s too late, shaving and bathing every couple of days, getting dressed, getting undressed, and th elike. Slow but independent mostly.

I have started writing an essay on Moses Maimnides’ A guife for the Perplexed and willinclude it here when it is more orless complete. Basically henotes the four types of perfection that humans seek: material goods, physical perfection, social ethics, and seeking truth, or knowledge. I address these in more detail in the essay, but the bottom linr id hid: We need enough material possessions to be sa independent as possible for as long as possile, we need to stay active and physically fit enugh that we don’t cause  medical issues,  we should be ethical in our dealings with others, and we should seek the truth, which ti me means using the scientific mehtod to determine which treatments work best for which patients, what causes different illnesses, and how “fuzzy” logic might help us to get closer to the truth in some cases than strict categorical thinking..

Maimonides clearly though that he last of these was the “highest” form of perfectiontobe sough sfter, while I argue that a balanceamongst allfour of these elements is best.

That will come later. For I havemiles to go befoe I go to sleep and will not go gently into that good night anytime soon, to plagiarize a couple of famous dead poets..