Tag Archives: Research
Keep on moving to (and making) music
The evidence that rhythm, movement, and making music continues to accumulate as a therapeutic approach to address the symptoms and Quality of Life issues related to Parkinson’s Disease (PD).
Today we look at an article just out in Frontiers of Human Neuroscience, titled
Over the last quarter of a century, increasing research results point to rhythm and music as effective and useful tools for treatment and rehabilitation of people with neurological disorders. This article reviews the evidence for four different approaches, what the consensus is at the present time, and, of course, suggests future directions.
The authors look at four different approaches:
- Rhythmic Auditory Stimulation (RAS)
- Music-Supported Therapy (MST)
- Therapeutic Instrumental Music Performance therapy (TIMP) and
- Patterned Sensory Enhancement (PSE)
The consensus of recent meta-analyses and systematic reviews is that, for Parkinson’s Disease (PD), is that RAS is an effective tool for improving gait, stride, and speed – folks walk faster and with longer steps with RAS. Additionally, evidence is showing that it also reduces freezing of gait (FOG), improves balance and reduces the occurrence of falls.
Neither MST nor TIMP have been studied much beyond the rehabilitation of stroke patients. They involve practicing on a keyboard or drums, beginning with the patient’s comfort level and increasing in difficulty. Some studies have begun to be used to investigate effectiveness as treatments for PD. Some have shown improvements in motor dexterity. More research is needed, but in the meantime, learning to play drums or keyboards can’t hurt, and may enrich one’s quality of life (QOL).
Growing evidence in neurological and brain imaging have shown increased activity in the auditory and motor areas of the brain, indicating that brain plasticity might be achieved through music and rhythmic interventions. The authors note that RAS has been well studied with stroke and PD populations, but not with other movement disorders and Alzheimer’s populations. In addition MST and TIMP have only begun to be investigated as a means of restoring fine motor coordination.
The authors also call for neuroimaging use in studies, to better understand the physiological basis of the rehabilitation process. They point out the gaps in research and hope to provide a framework for future research – not so much a roadmap, I would think, but a laying out of what we know and what we don’t know, and what kinds of studies are needed to answer the questions about what we don’t know.. They state that “musical rhythm is a powerful tool” for therapy, and our understanding and exploration of how it modulates brain networks is in the initial stages.
In other words, “We’ve only just begun.”
Meanwhile: Don’t stop moving to the music.
Citation:
Braun Janzen T, Koshimori Y, Richard NM and Thaut MH (2022) Rhythm and Music-Based Interventions in Motor Rehabilitation: Current Evidence and Future Perspectives. Front. Hum. Neurosci. 15:789467. doi: 10.3389/fnhum.2021.78946
A global resource
Who would have guessed it?
There is now a checklist for all the vascular plants on the globe. Actually, probably many folks could have guessed it – this is what the internet was invented for, not for sharing cute kitten pictures on Facebook or Instagram (sorry, don’t mean to offend anyone. I like cute kitten pictures, too).
In an article (open access) published on nature.com, you will find The World Checklist of Vascular Plants, a continuously updated resource for exploring global plant diversity. The DOI reference is https://doi.org/10.1038/s41597-021-00997-6 where you can find the actual citation to use:
Govaerts, R., Nic Lughadha, E., Black, N. et al. The World Checklist of Vascular Plants, a continuously updated resource for exploring global plant diversity. Sci Data 8, 215 (2021). https://doi.org/10.1038/s41597-021-00997-6
There have been other checklists, and the authors provide a table explaining the differences.
To maximise utility, such lists should be accessible, explicitly evidence-based, transparent, expert-reviewed, and regularly updated, incorporating new evidence and emerging scientific
consensus. WCVP largely meets these criteria, being continuously updated and freely available online. Users can browse, search, or download a user-defned subset of accepted species with corresponding synonyms and bibliographic details, or a date-stamped full dataset
The World Checklist of Vascular Plants (WVCP)
As sloppy as I am as a scientist, I might not make use of this as often as I should. But I’ll post it, and maybe someone else will get more use out of it than I will. Who knows? Maybe I’ll make more use of it, having shared this post.
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Not a cure, but a biomarker
A biomarker for Parkinson’s? Maybe… (If you don’t have a free ResearchGate account, yu might not be able t see this link):
A blood marker for Parkinson’s Disease: Neuronal exosome-derived α-synuclein
This isn’t in print yet, so I’ll just quote frm the abstract:
18 To date, no reliable clinically applicable biomarker has been established for Parkinson’s
19 disease (PD). Our results indicate that a long hoped blood test for Parkinson’s disease may
20 be realized. We here assess the potential of pathological α-synuclein originating from
21 neuron-derived exosomes from blood plasma as a possible biomarker. Following the
22 isolation of neuron-derived exosomes from plasma of PD patients and non-PD individuals
23 immunoblot analyses were performed to detect exosomal α-synuclein. Under native
24 conditions significantly increased signals of disease-associated α-synuclein forms in neuron25 derived exosomes were measured in all individuals with PD and clearly distinguished PD
26 samples from controls. By performing a protein misfolding cyclic amplification assay these
27 aggregates could be amplified and seeding could be demonstrated. Moreover, the
28 aggregates exhibited β-sheet-rich structures and showed a fibrillary appearance. Our study
29 demonstrates that the detection of pathological α-synuclein conformers from neuron-derived
30 exosomes from plasma samples has the potential of a promising blood-biomarker of PD.
Exosomes are small bundles of proteins enclosed by a membrane (if I understand it correctly)(feel free to correct me- the Wikipedia article hd a note saying that it was too technical for most readers – and I agree).
Exosomes contain material from the cells from which they originated, so might be used as biomarkers. Obviously, it will take a while to fund the research and develop some way to determine how far along the way to developing PD someone is. But the sooner a person can deal with it, the better the opportunity to live well with it. I look forward to the development of biomarkers that will help predict who might get Parkinson’s, so those folks can take preventive action.
I am fortunate that my symptoms did not appear in the usual sequence,and that I had DBS early after diagnosis, have had an outstanding medical team looking out for me and working with me, have a strong local community supporting people with Parkinson’s, and have a care partner who makes sure that my diet is full of organic foods, produce, and as few highly processed foods as possible. And I get lots of exercise, considering that I’m not athletic and I am not into weightlifting or bodybuilding.
Lucky me.
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Some research that might be of interest…
My Google Scholar alert feed tossed a couple of items my way that might be of interest. They are in PDF format, so you can read them online or download them for future reference:
Tricky partners: native plants show stronger interaction preferences than their exotic counterparts.
Citation: Coux, C., I. Donoso, J. M. Tylianakis, D. Garcı´a, D. Martı´nez, D. M. Dehling, and D. B. Stouffer. 2021. Tricky partners: native plants show stronger interaction preferences than their exotic counterparts Ecology 102(2):e03239. 10.1002/ecy.3239
Main takeaway (my interpretation): Increasing presence of exotic plants may put rare native plants at higher risk of extinction.
(Caveat: my browser says the site is not secure. However, I have several security programs that (hopefully) would mitigate. the risks).
That being said, the article is from a group of scientists from New Zealand, Germany and Spain who looked into the interactions that native and exotic plant species had with other plant species.
Exotic species interact with many partners with which they have not coevolved, and it remains unclear whether this systematically influences the strength of neutral processes on interactions, and how these interaction-level differences scale up to entire networks. To fill this gap, we compared interactions between plants and frugivorous birds at nine forest sites in New Zealand varying in the relative abundance and composition of native and exotic species, with independently sampled data on bird and plant abundances from the same sites
The results found that native plants’ interactions with birds were both more positive (preference for) and negative (avoidance of). Their analysis suggests that the blending of species communities through dispersal of exotics into native plant communities might result in an increase of neutral interactions between birds and native plants or exotic plants.
This could make rare species more vulnerable to this loss of selectivity and to greater randomness in the identity of their interaction partner.
So there’s another argument for getting rid of invasives.
Moving right along, here comes
…found that native grass cover decreased dramatically (especially on the valley floor), exotic grass cover fluctuated widely over time, while both native and exotic forb cover increased over time. The findings support the notion that prior grazing management practices may have supported the former stands of Stipa pulchra.
… Several trends became apparent when the data from the three periods are viewed together. Both native and exotic forbs increased between each data collection. There were consistently more native forbs than exotic ones and native grasses decreased in cover. Though exotic grasses fluctuated, they always made up a greater amount of cover than their native counterparts. Lastly, cover of bare ground fluctuated and shrubs declined. The Fisher’s Exact test of the increases and decreases of forb and grass cover across quadrats from 1981 to 2015 had a p-value of 0.00012 indicating that we can reject the null hypothesis of independence…
… native bunchgrasses have declined dramatically since the end of the ranching era. Simultaneously, native forbs have increased (at least temporarily), especially on the valley floor. Our findings also suggest that the historical ranching practices in LJV likely supported the excellent stands of Stipa observed in the valley prior to release from grazing. These findings are in agreement with those of previous long-term studies in other parts of California that also found a decline in Stipa cover on lands released from grazing. (emphasis added).
If one were to generalize the conclusions of this study to Texas, where this writer resides, I would say that the presence of large stands of Prickly Pear (Opuntia sp.). and Texas Cedars (Juniperus ashei) as the dominant species in large parts of Central Texas is probably due to past practices of overgrazing, similar to the presence of the native bunchgrasses in California has been attributed to the previous grazing practices in the study cited above.
However, I do not believe that the answer to the problem is to bulldoze the soil away and to cover the land with non-permeable surfaces like buildings and asphalt parking lots. One can develop land while leaving large portions of native plant species intact, and without replacing them with crappy myrtles and Nandina plants.
postscript:
One of the references used in the article on California grasses was California’s Fading Wildflowers by Richard A. Minnich. The table of contents and lists of illustrations and tables and preface are available for open access, but the book itself costs a hefty $128.00. Another reference was Terrestrial Vegetation of California. California Native Plant Society Special Publication Number 9 (pp. 733–760). Sacramento, California., which is not on the web.
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Cannabis and Parkinson’s Disease (PD)
This article popped up in my email alerts. Although I do not have access to the journal in which it appeared, I thought I would post it anyway, along with several article titles that appeared in the same journal. (If my former employer would grant me access to their technical library, I would be most grateful, and might even forego any patent filing awards that I would be eligible for if I hadn’t retired. I come across at least one new Human-Computer Interface issue that could be solved each week, But I digress). (The actual link to the article was in Medscape News).
Despite high interest (no pun intended(?)) in the use of cannabis as a treatment for Parkinson’s Disease symptoms, this study finds that actual use remains low (at least in Germany). The article appeared in Journal of Parkinson’s Disease: Yenilmez, Ferhat et al. ‘Cannabis in Parkinson’s Disease: The Patients’ View’. 1 Jan. 2021 : 309 – 321. 11, no. 1, pp. 309-321, 2021.
Sadly, it is not available as open access, but fortunately the methods and results provide adequate data regarding the study.
Abstract:
Background: Little is known about the patients’ view on treatment with medical cannabis (MC) for Parkinson’s disease (PD). Objective: To assess the PD community’s perception of MC and patients’ experience with MC.Abstract:
Methods: Applying a questionnaire-based survey, we evaluated general knowledge and interest in MC as well as the frequency, modalities, efficacy, and tolerability of application. Questionnaires were distributed nationwide via the membership journal of the German Parkinson Association and locally in our clinic to control for report bias.
Results: Overall, 1.348 questionnaires (1.123 nationwide, 225 local) were analysed. 51% of participants were aware of the legality of MC application, 28% of various routes of administration (ROA) and 9% of the difference between delta9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD).
PD-related cannabis use was reported by 8.4% of patients and associated with younger age, living in large cities and better knowledge about the legal and clinical aspects of MC. Reduction of pain and muscle cramps was reported by more than 40% of cannabis users. Stiffness/akinesia, freezing, tremor, depression, anxiety and restless legs syndrome subjectively improved for more than 20% and overall tolerability was good. Improvement of symptoms was reported by 54% of users applying oral CBD and 68% inhaling THC-containing cannabis. Compared to CBD intake, inhalation of THC was more frequently reported to reduce akinesia and stiffness (50.0% vs. 35.4%; p < 0.05). (emphasis added) Interest in using MC was reported by 65% of non-users.
Conclusion: MC is considered as a therapeutic option by many PD patients. Nevertheless, efficacy and different ROA should further be investigated.
Some other articles on the same issue that might be of interest (All are at the above link):
The Subjective Experience of Living with Parkinson’s Disease: A Meta-Ethnography of Qualitative Literature
Does Gut Microbiota Influence the Course of Parkinson’s Disease? A 3-Year Prospective Exploratory Study in de novo Patients
Association Between Thyroid Diseases and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort ” The rates of levothyroxine treatment for more than 3 months, hypothyroidism, and hyperthyroidism were higher in the PD group than the control group (3.2%, 3.8%, and 2.8% vs. 2.5%, 2.9%, and 1.9%, respectively, p < 0.05). The adjusted odds ratios (ORs) in model 2, which was adjusted for all potential confounders, for hypothyroidism and hyperthyroidism in the PD group were 1.25 (95% confidence interval (CI) 1.01–1.55, p = 0.044) and 1.37 (95% CI 1.13–1.67, p = 0.002), respectively.
Subthalamic Stimulation Improves Quality of Sleep in Parkinson Disease: A 36-Month Controlled Study
Diet Quality and Risk of Parkinson’s Disease: A Prospective Study and Meta-Analysis
Identification of Pre-Dominant Coping Types in Patients with Parkinson’s Disease: An Abductive Content Analysis of Video-Based Narratives
Dissonance in Music Impairs Spatial Gait Parameters in Patients with Parkinson’s Disease “ Conclusion: Our observations suggest that dissonant music negatively affects particularly spatial gait parameters in PD by yet unknown mechanisms, but putatively through increased cognitive interference reducing attention in auditory cueing.”
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Discrete choice experiment
Published in the Australian Journal of Physiotherapy as an open access article, we have an experiment in which several factors were used to determine participants’ preferences in a hypothetical exercise program.
Conclusions were:
People with Parkinson’s disease were more willing to participate in exercise programs that cost less, involve less travel, provide physical or psychological benefits and are supervised by qualified professionals. To enable more people with Parkinson’s disease to exercise, health services should provide programs addressing these factors and account for sex differences. [emphasis added. Men were more likely to favor strength training, women were averse to aerobic exercise, and folks already exercising 300 minutes per week were less likely to favor adding more exercises.]
The group to which I subscribe on their YouTube channel, and support in various ways, is Power For Parkinson’s® (PFP). I also am a member of the Georgetown Area Parkinson’s Support group (GAPS) and the Capital Area Parkinson’s Society (CAPS) Both PFP and GAPS sponsor several exercise groups aimed directly at people with Parkinson’s Disease (PD) and their needs, so I am usually working out at least one hour daily. So I might fall into the last group of folks not willing to add more exercises.
On a different tangent, A couple of articles showed up that deal with the idea of Multiple Intelligences. Actually, one is a book excerpt with selected portions available on Google Books, and the other is the cover, Table of Contents, Bibliography, and Index of a different book. Granted, the Index does list Parkinson’s Disease on at least 2 pages. Why bother? Because, as those who have read the earlier blog post(s) on Moses Maimonides and Me, I don’t particularly subscribe to Maimonides’ categories of four ways in which humans strive to achieve perfection.
These books are:
Eastern European Perspectives on Emotional Intelligence
in which some of the available pages include charts of Howard Gardner’s Multiple Intelligences, and some of the results which seem to show a clustering of several factors (using factor analysis). Since that is outside of my area of expertise, I won’t comment on it. (This is all copyrighted material, provided only for personal education, etc.
The other is Mind Ecologies: Body, Brain and World which has the extensive bibliography and index. Probably well worth looking into the bibliography, if one has a mind to do so (but not today). The TOC reads:
1. Life, Experimentalism, and Valuation 16
2. Pragmatism and Embodied Cognitive Science 51
3. Social Cohesion, Experience, and Aesthetics 94
4. Pragmatism and Affective Cognition 124
5. Perception, Affect, World 156
6. Broadening Ecologies 184
and the whole thing is copyright The Columbia University Press.
My pulmonologist prescribed a nap in the morning and afternoon, and since I missed the morning nap, will head off to do one this afternoon.
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