An interesting development, or in this case, two interesting developments, is the finding that currently available medications might be repurposed for their neuroprotective effects. Here are two articles on two drugs that show promise.

This is a report on a hypertension medication that provides neuroprotection in mice and may be transferable to humans… Are mice brains similar enough to humans for it to work? A recent report on isradipine, another hypertension medication, reported no differences in symptoms between controls and those receiving the medications. We shall see.

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Nrct we have a case in which a tricyclic antidepressant, nortriptyline, has been found to slow down the aggregation of alpha synuclein proteins in the brain.

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein

 Not sure whether either will pan out, but anyone with either hypertension or depression could discuss these articles with their doctor(s) and come to a mutually agreeable course of action.

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